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On February 4th, Novo Nordisk (NVO.N) shares listed in the US fell more than 13% on Tuesday after the company unexpectedly warned that its 2026 sales would decline more sharply than expected, due to price pressures impacting sales of its best-selling diabetes and weight-loss drugs in the US. The Danish company stated that it expects global sales for the full year of 2026 to decline by 5% to 13% compared to 2025 levels (excluding currency fluctuations). In contrast, sales grew by 10% in 2025. The company stated that US sales would decrease due to price reductions for drugs including Ozempic and Wegovy. They noted that the company recently reached an agreement with the Trump administration to lower drug prices. The main ingredients of these two drugs will also lose patent exclusivity in some countries outside the US, potentially opening up opportunities for low-priced generic competition. This deteriorating outlook is yet another piece of bad news for this once-rapidly growing company, a pioneer in the weight-loss drug market.The Nasdaq China Golden Dragon Index fell further to 2%, with WeRide (WRD.O) and Bilibili (BILI.O) dropping more than 5%, and Alibaba (BABA.N) and iQiyi (IQ.O) falling more than 4%.The Federal Reserve accepted a total of $1.785 billion from 18 counterparties in its fixed-rate reverse repurchase operations.On February 4th, Russian President Vladimir Putin stated on February 3rd that Russias GDP growth in 2025 is projected to be 1%, a slowdown in line with expectations. Speaking at a meeting on economic issues in Moscow, Putin said that Russias economic growth rate in 2025 will be lower than the 4.1% of 2023 and 4.3% of 2024. He stated that the slower economic growth in 2025 is in line with expectations, mainly due to specific measures aimed at reducing inflation. Putin explained that Russias inflation rate in 2025 has already fallen to 5.6%, lower than 9.5% in 2024. Furthermore, as of January 26th, Russias annualized inflation rate this year was 6.4%. Putin expects the inflation rate to potentially fall to 5% this year. Putin pointed out that Russias current task is to restore economic growth, improve the business environment, and attract investment by increasing production capacity. These measures have been incorporated into the economic restructuring plan until 2030.White House Press Secretary: U.S. Special Envoy Witkov has left and is preparing to meet with Iranian officials; negotiations are proceeding as planned.

US open: Stocks Head Lower, Twitter, Big Tech in Focus

Cory Russell

Apr 27, 2022 10:53

The Headlines on Twitter

Following a strong finish in the previous session and ahead of the commencement of large tech results, US markets are expected to start lower. Inflation has been a major subject this earnings season, and investors will be watching for clues about the impact of inflation on consumer spending when the numbers come in.


The statistics from the United States showed that durable goods rose 0.8 percent in March, up from 1.7 percent in February, but still falling short of the 1 percent expectation.

 

Looking forward Consumer confidence in the United States is predicted to improve to 108.00 from a 10-month low later this afternoon. This would be the first time in four months that it has improved, despite rising prices. Interestingly, despite a drop in consumer confidence, Americans have continued to spend, with retail sales remaining largely stable.

In TheBusiness World:

Twitter is up 0.2 percent in premarket trading as investors digest the news that Elon Musk has purchased the social media company after the board approved a $44 billion deal to take it private.


Elon Musk has already stated that he may not seek to monetize Twitter; instead, his goal is to make it a more transparent and fair platform for free speech.

 

In the next months, profits will pick up a notch, with large tech earnings taking center stage. Earnings growth is likely to slow in general. However, Microsoft is expected to disclose record earnings after the market closes today. Despite this, the stock has underperformed.

 

After the closing, Alphabet is also expected to report. On revenue of $68.13 billion, EPS of $25.63 is expected.

Where Does the S&P500 Go From Here?

The S&P500 hit resistance at the 100 sma at 4510, then dropped below the 50 sma, finding support at 4200. While trading out of oversold territory, the RSI is below 50, suggesting potential decline. 


A break below 4210/4200 could open the door to 4140 if the index breaks below it. Meanwhile, the extended lower wick on the candle to 4200 could stimulate buyers, implying that the price did not find much acceptance at these lower levels, therefore propelling the price higher. Buyers are attempting to break through resistance at 4280, with a move above exposing the 50 sma at 4400.