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NASA: Artemis program astronauts have completed half of their lunar mission.According to Irans Mehr News Agency, a missile attack occurred in northern Tehran, resulting in one casualty.On April 4th, it was reported that TrueEV, XPengs exclusive distributor in Australia, entered administration (bankruptcy management) proceedings, drawing attention. XPeng responded that during the past two years of cooperation, it learned through various channels that TrueEV had experienced a broken cash flow and was under the control of its financing party, and had not purchased any vehicles for over a year, failing to fulfill order obligations including 454 cars. TrueEV also had a public business conflict with local dealers, severely damaging the foundation of trust between the two parties. Therefore, in accordance with the cooperation agreement, XPeng formally issued a breach of contract notice to TrueEV, terminating its exclusive distributorship, but retaining its distributorship status. However, TrueEV denied the aforementioned operational problems and instead pursued legal action against XPeng. The Australian court rejected its injunction application on April 1st. XPengs goal going forward is to establish itself in Australia within the next three years as a technology brand that is not only technologically advanced but also trustworthy in terms of user experience.On April 4th, it was reported that the international standard proposal for "DC Filter Capacitors for High Voltage Direct Current Transmission Systems," initiated by my country, was recently approved by the International Electrotechnical Commission (IEC). This standard is the first international standard specifically addressing DC filter capacitors in the field of high voltage direct current transmission, filling a gap in related professional standards. The standard was led by Chinese experts, with participation from experts from Italy, France, Germany, and other countries. The development of this standard will facilitate the sharing of advanced technological concepts of Chinas core high voltage direct current transmission equipment with the world, contributing more Chinese strength to global energy transition and power system upgrading.April 4th - Data released by the General Statistics Office of Vietnam shows that Vietnams economy slowed compared to the previous quarter due to heavy reliance on Middle Eastern oil imports. Vietnams GDP grew by 7.83% in the first quarter, lower than the 8.46% in the fourth quarter of last year. The Vietnamese governments growth target for this year is no less than 10%, but this target is currently under pressure. Vietnam imports over 80% of its crude oil from the Middle East, and oil shipments from the region have been disrupted due to the conflict with Iran. Rising fuel prices have forced Vietnamese airlines to scale back operations and prompted authorities to introduce cost-control measures, including reducing fuel taxes, subsidizing prices through government-controlled funds, and encouraging remote work to reduce consumption.

AstraZeneca's nasal spray vaccine trial for COVID experiences a setback

Charlie Brooks

Oct 11, 2022 11:23

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Tuesday, attempts by researchers from Oxford University and AstraZeneca (NASDAQ:AZN) Plc to manufacture a nasal-spray version of their jointly developed COVID-19 injection were hindered by the failure of first human tests to give the required degree of protection.


During the first of generally three phases of clinical testing, a minority of trial participants had an antibody response in their respiratory mucous membranes, according to a statement released by the University of Oxford on Tuesday.


In addition, the immune response measured in the blood was weaker than that caused by an arm injection.


Researchers from throughout the world have high hopes for nasal spray vaccinations against the coronavirus, as it is predicted that the method could prevent infection and illness by stimulating an immune response directly in the airways, where the virus enters the body.


In addition, the method would be less painful and easier to administer than injections.


In India and China, regulators have previously authorized the administration of drugs via the airways.


Last month, India's health minister approved Bharat Biotech's COVID-19 nasal spray vaccine, while China's medicines regulator approved CanSino Biologics Inc's COVID-19 inhaled vaccine on an emergency basis.


CanSino has said that its nebuliser-delivered vaccine can develop robust immunity to successfully restrict disease, but Bharat's trial findings are not yet available.


The British study included 30 unvaccinated patients and 12 volunteers who had previously undergone a normal two-dose immunization course.


In this study, the nasal spray did not perform as well as anticipated, according to Sandy Douglas, the trial's primary investigator at the Jenner Institute of Oxford University.


She went on to say, "We believe that delivery of vaccinations through the nose and lungs remains a viable option, but this study suggests that there will be challenges in making nasal sprays a reliable alternative."


During the AstraZeneca-funded trial, no severe adverse events or safety concerns were reported, according to the release.

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